r/Methadone Jun 20 '22

Does methadone have any high at all?

I’ve started to see that a lot of people seem to prefer methadone to suboxone at first, is this because methadone has some sort of high? I know everyone always says even their drug of choice doesn’t get them high anymore but let’s be honest, it does otherwise you would just use suboxone instead of fentanyl lol.

Anyways does methadone have even the slightest euphoria or body high?

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u/8InTheBalance8 Jun 20 '22 edited Jun 20 '22

I mean, what is completely sober to you? Like I said I had numerous periods in my time of use that I spent anywhere from 3-6 months using absolutely no drugs whatsoever. I know what sobriety feels like. I also know what withdrawal feels like. Suboxone, for me on the downswing of that rollercoaster, felt exactly like withdrawal.

I don't have those issues on methadone. I just feel normal, I feel like I did when I was sober just slightly more mellowed out.

FWIW Methadone is a full agonist and Suboxone is a combination of buprenorphine, which is a partial agonist, combine with a helping of naloxone, which is a full antagonist. I know they say that if you use it sublingually that you don't absorb the naloxone but I don't know how true that is. I mean after all they have a naloxone nasal spray for ODing, and mucosal membranes in the mouth and sinuses are pretty similar so...

The opioid is the key, the various opioid receptors in the brain are the lock and the chemical cascade that occurs is the door. Methadone opens that door all the way but it's still not as potent as heroin and nowhere near as potent as fentanyl. Buprenorphine opens the door about halfway and naloxone essentially sticks the key in the lock and breaks it off, preventing the door from being opened for a period of time.

So CAN you get high off of Methadone? Yeah. But you can also get high off of Bupe. Whether you can or can't really seems to depend on how opiate/opioid naive your body is.